Nautilus Biotechnology

Biotech tools / proteomicsUSA
New to Unitard
πŸ“‰ Public < $1B
PeakΒ $1.5 BillionToday
βˆ’92%
from peak
  1. πŸ¦„
    Became a unicorn
    2021
  2. πŸ“ˆ
    Peak valuation
    $1.5 Billion ’21
  3. πŸ’”
    Became a Unitard
    2022
  4. πŸ’Έ
    Last valuation
    ~$124M
Current status
Public (Nasdaq: NAUT); product launch delayed to 2026, 16% layoffs (2025)
Live Β· NAUTΒ· NasdaqCM
as of 2026-09-17
$0.972β–Ό 1.85% today
β‰ˆΒ $124 Million market cap Β· βˆ’91.8% from peak

The rise & fall

5 moments Β· 2016–2025

The key moments.

2016
Founded to map the human proteome
Isilon co-founder Sujal Patel and Stanford scientist Parag Mallick set out to read every protein with a single-molecule platform.
GeekWire
Jun 2021
The peak: a ~$1.5B SPAC debut$1.5B
Merges with Perceptive Advisors' Arya Sciences Acquisition Corp III and trades above $10 a share β€” before the platform has shipped.
Businesswire
2022
Slips out of the club
The stock sinks with the rest of the de-SPAC class of 2021, falling below a $1B value on its way to a 90%-plus drawdown.
GeekWire
2022–24
The launch keeps receding
Commercialization targets slip year after year β€” eventually to late 2026 β€” while losses mount.
GeekWire
2025
16% of staff cut
With the platform still unlaunched and the market cap around $105M, Nautilus lays off 16% of its workforce.
GeekWire
Today
Still in the club β€” and still trading
Live Β· NAUT Β· NasdaqCMas of 2026-09-17
$0.972β–Ό 1.85% todayβ‰ˆ $124M cap Β· βˆ’91.8% from peak

How it happened

Nautilus Biotechnology aimed to map the entire human proteome with a single-molecule protein-analysis platform, and went public in June 2021 via a SPAC merger with Perceptive Advisors' Arya Sciences Acquisition Corp III, trading above $10 a share for a valuation over $1B.

The product proved hard to commercialize: launch timelines slipped repeatedly (now targeted for late 2026), losses mounted and the stock fell more than 90%. By 2025 Nautilus had cut 16% of staff and was worth only around $100M β€” a fraction of its debut.

Source: Businesswire / GeekWire / SEC (SPAC merger with Arya Sciences Acquisition Corp III, closed June 2021, traded >$10/share at >$1B; ~$105M market cap 2025; commercial platform delayed to 2026; 16% layoffs)

Founders

  • Sujal Patel
    Co-founder & CEO (also Isilon founder)
    Still there β€” Founder, CEOLinkedIn β†—
  • Parag Mallick
    co-founder
    Now Associate Professor at Stanford UniversityLinkedIn β†—

Current roles as self-reported on LinkedIn, retrieved 2026-08-19. See our methodology.

More from the club

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